to produce a change in somebody/something

to attack somebody or a part of the body; to make somebody become ill

The disease is more likely to affect women than men.

The condition affects one in five women.

Rub the cream into the affected areas.

to make somebody feel very sad, sorry, etc. about somebody/something

They were deeply affected by the news of her death.

Try not to let his problems affect you too much.

to pretend to be feeling or thinking something

She affected a calmness she did not feel.

We are fascinated by the rich and powerful but often affect to despise them.

to use or wear something that is intended to impress other people

I wish he wouldn't affect that ridiculous accent.

LEARNit Dictionary